Job
Post-doctoral position, Porter lab
Organization
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD and surrounding area
Scientific focus area
Neuroscience, Genetics and Genomics
The laboratory of Dr. FD Porter at NIH is seeking a skilled candidate for gene therapy work in a rare, inherited disease. Applicants should be seeking a post-doc, be highly motivated, and have direct gene therapy experience. We’re looking for someone to hit the ground running as this project is well underway and moving towards the clinic. Super productive lab, great coworkers, supportive and engaged Principal Investigator, a win for all…so long as you have a strong background in gene therapy!
About the position
The Section on Molecular Dysmorphology in the intramural research program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development is a combined Clinical and Basic research team that is looking for a Postdoctoral Fellow with experience in gene therapy who can complement and advance our efforts to develop therapies for rare genetic disorders. Understanding the neuropathology and identifying potential therapeutic interventions for Niemann-Pick type C (NPC) disease is currently the major focus of our basic/translational research group. NPC is a progressive neurodegenerative disorder that primarily affects children. We utilize multiple preclinical models including neurons derived from induced pluripotent stem cells and mouse models. Advanced sequencing technologies, including single nuclear RNAseq and spatial transcriptomics, will be used to gain insight into pathological mechanisms. High throughput drug and genome-wide sgRNA screens are helping elucidate potential drugs or druggable pathways. Proteomic and lipidomic studies are being used to identify biomarkers important for facilitating clinical trials. We are now looking to expand our AAV9-mediated gene therapy efforts with the goal of advancing to a clinical trial. An individual with experience in gene therapy and a desire to contribute to the development of therapies for a rare disease would be an impactful addition to our team.
Apply for this vacancy
What you'll need to apply
Interested candidates should email a CV, statement of research interest and the names of three references to cristin.davidson@nih.gov.
Contact name
Cristin Davidson
Contact email
Qualifications
Candidates with a PhD in Biological Sciences, or a related field and less than 5 years of prior postdoctoral experience are encouraged to apply. Bench experience with gene therapy and preclinical disease models is required. Strong knowledge of computational methods to study biochemistry/biology is a plus.
Disclaimer/Fine Print
Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities.
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