Job
Postdoctoral Fellow
Organization
Eunice Kennedy Schriver National Institute of Child Health and Human Development, Bethesda, MD and surrounding area
Scientific focus area
Neuroscience, Genetics and Genomics
The Porter lab at NICHD is a group of scientists and clinicians working to advance therapies for rare, fatal genetic disorders. Collaboration, motivation, and scientific curiosity are driving forces behind our work.
About the position
The Section on Molecular Dysmorphology in the intramural research program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development is a combined Clinical and Basic research team that is looking for a Postdoctoral Fellow with experience in gene therapy who can complement and advance our efforts to develop therapies for rare genetic disorders. Understanding the neuropathology and identifying potential therapeutic interventions for Niemann-Pick type C (NPC) disease is currently the major focus of our basic/translational research group. NPC is a progressive neurodegenerative disorder that primarily affects children. We utilize multiple preclinical models including neurons derived from induced pluripotent stem cells and mouse models. Advanced sequencing technologies, including single nuclear RNAseq and spatial transcriptomics, will be used to gain insight into pathological mechanisms. High throughput drug and genome-wide sgRNA screens are helping elucidate potential drugs or druggable pathways. Proteomic and lipidomic studies are being used to identify biomarkers important for facilitating clinical trials. We are now looking to expand our AAV9-mediated gene therapy efforts with the goal of advancing to a clinical trial. An individual with experience in gene therapy and a desire to contribute to the development of therapies for a rare disease would be an impactful addition to our team.
Apply for this vacancy
What you'll need to apply
Interested candidates should email a CV, statement of research interest and the names of three references to cristin.davidson@nih.gov.
Contact name
Cristin Davidson
Contact email
Qualifications
Candidates with a PhD in Biological Sciences, or a related field and less than 5 years of prior postdoctoral experience are encouraged to apply. Bench experience with gene therapy and preclinical disease models is required. Strong knowledge of computational methods to study biochemistry/biology is a plus.