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Job

Mass Spectrometry Resource

Organization

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD and surrounding area

Scientific focus area

Chemical Biology, Structural Biology, Molecular Pharmacology

The Laboratory of Bioorganic Chemistry (LBC) in NIDDK seeks an experienced mass spectrometrist to support research in the discovery and development of new classes of pharmacological agents. An integral part of this research involves the development and application of modern techniques in organic, medicinal and analytical chemistry.

About the position

The successful candidate will be responsible for operating and maintaining an advanced research grade LC/MS/MS mass spectrometry resource. The LC/MS/MS data provided by this instrumentation is critical for a wide variety of research areas and supports chemists and chemical biologists engaged in cutting edge biomedical research. The most important role of this position is to be able to operate and maintain the sophisticated and complex HRMS instrumentation in a way that maximizes the quality of the MS data generated and to also make the instrument available to as many scientists as possible.

Apply for this vacancy

What you'll need to apply

CV, bibliography, statement of interest and experience relative to the job, list of 3 references

Contact name

Carole Bewley

Contact email

caroleb@nih.gov

Qualifications

The following qualifications are required:

  • PhD in organic chemistry, analytical chemistry, or a mass spectrometry-related field.
  • Demonstrated ability to work independently as substantiated by scientific publications in mass spectrometry related areas.
  • Postdoctoral or industry experience in operating and maintaining HRMS and HPLC or UPLC instrumentation.
  • Knowledge of organic chemistry and the ability to use MS or MS/MS data to help determine structures and yield and/or success of reactions or enzymatic transformations.

Preferred experience or qualifications include the following:

  • Experience with performing accurate mass measurements on molecules ranging from small, synthetic, organic, drug-like compounds; peptides and natural products in the 1-5 kDa molecular weight range; synthetic oligomers such as nucleic acids and peptide nucleic acids (PNAs); nanobodies and antibodies and their chemical conjugates with mwt ranges up to 80 kDa; and glycosylated molecules with a large mwt range.
  • Demonstrated ability to work as part of a team and to provide rapid turnaround of HRMS data Experience with leading a MS facility or resource and tracking users, sample types, and methods used

Disclaimer/Fine Print

Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

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